Articles
Patents

Articles

2021


225. "Iodine-Mediated Tryptathionine Formation Facilitates the Synthesis of Amanitins."
Yao, G., Knittel, C.H., Kosol, S., Wenz, M.T., Keller, B.G., Gruß, H., Braun, A.C., Lutz, C., Hechler, T., Pahl, A., Süssmuth*, R.D.
J. Am. Chem. Soc. 2021, https://doi.org/10.1021/jacs.1c06565

224. "Overcoming AlbD protease resistance and improving potency: Synthesis and bioactivity of antibacterial albicidin analogues with amide bond isosteres."
Kleebauer, L., Zborovsky, L., Hommernick, K., Seidel, M., Weston, J., Süssmuth*, R.D.
Org. Lett. 2021, https://doi.org/10.1021/acs.orglett.1c02312

223. "Hexapod Assassins' Potion: Venom Composition and Bioactivity from the Eurasian Assassin Bug Rhynocoris iracundus."
Rügen, N., Jenkins, T.P., Wielsch, N., Vogel, H., Hempel, B.F., Süssmuth, R.D., Ainsworth, S., Cabezas-Cruz, A., Vilcinskas, A., Tonk, M.
Biomedicines. 2021, 9(7), 819.

222."Labyrinthopeptin A inhibits dengue and Zika virus infection by interfering with the viral phospholipid membrane."
Oeyen, M., Meyen, E., Noppen, S., Claes, S., Doijen, J., Vermeire, K., Süssmuth, R.D., Schols, D.
Virology. 2021, 562, 74-86

221."An ultrafast and flexible LC-MS/MS system paves the way for machine learning driven in vivo sample processing and data evaluation in early drug discovery."
Häbe, T.T., Späth, C., Schrade, S., Jörg, W., Süssmuth, R.D., Bischoff, D., Luippold, A.H.
Rapid Commun. Mass Spectrom. 2021, 35(12), e9096

220. "Acetylenic Replacement of Albicidin's Methacrylamide Residue Circumvents Detrimental (E)-(Z)-Photoisomerization and Preserves Antibacterial Activity."
Behroz, I., Kleebauer, L., Hommernick, K., Seidel, M., Grätz, S., Mainz, A., Weston, J.B., Süssmuth*, R.D.
Chemistry. 2021, 27(35), 9077-9086

219. "A community resoruce for paired genomic and metabolomic data mining."
Schorn, M.A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D.D., Aksenov, A.A., Aleti, G., Moghaddam, J.A., Aron, A.T., Aziz, S., Bauermeister, A., Bauman, K.D., Baunach, M., Beemelmanns, C., Beman, J.M.,
Berlanga-Clavero, M.V., Blacutt, A.A., Bode, H.B., Boullie, A., Brejnrod, A., Bugni, T.S., Calteau, A., Cao, L., Carrión, V.J., Castelo-Branco, R., Chanana, S., Chase, A.B., Chevrette, M.G., Costa-Lotufo, L.V.,
Crawford, J.M., Currie, C.R., Cuypers, B., Dang, T., de Rond, T., Demko, A.M., Dittmann, E., Du, C., Drozd, C., Dujardin, J.C., Dutton, R.J., Edlund, A., Fewer, D.P., Garg, N., Gauglitz, J.M., Gentry, E.C.,
Gerwick, L., Glukhov, E., Gross, H., Gugger, M., Guillén, Matus, D.G., Helfrich, E.J.N., Hempel, B.F., Hur, J.S., Iorio, M., Jensen, P.R., Kang, K.B., Kaysser, L., Kelleher, N.L., Kim, C.S., Kim, K.H., Koester, I.,
König, G.M., Leao, T., Lee, S.R., Lee, Y.Y., Li, X., Little, J.C., Maloney, K.N., Männle, D., Martin, H.C., McAvoy, A.C., Metcalf, W.W., Mohimani, H., Molina-Santiago, C., Moore, B.S., Mullowney, M.W., Muskat, M.,
Nothias, L.F., O'Neill, E.C., Parkinson, E.I., Petras, D., Piel, J., Pierce, E.C., Pires, K., Reher, R., Romero, D., Roper, M.C., Rust, M., Saad, H., Saenz, C., Sanchez, L.M., Sorensen, S.J., Sosio, M., Süssmuth, R.D.,
Sweeney, D., Tahlan, K., Thomson, R.J., Tobias, N.J., Trindade-Silva, A.E., van Wezel, G.P., Wang, M., Weldon, K.C., Zhang, F., Ziemert, N., Duncan, K.R., Crüsemann, M., Rogers, S., Dorrestein, P.C., Medema, M.H.,
van der Hooft, J.J.J.
Nat. Chem. Biol. 2021, 17(4), 363-368

218. "Eliciting the silent lucensomycin biosynthetic pathway in Streptomyces cyanogenus S136 via manipulation of the global regulatory gene adpA."
Yushchuk, O., Ostash, I., Mösker, E., Vlasiuk, I., Deneka, M., Rückert, C., Busche, T., Fedorenko, V., Kalinowski, J., Süssmuth, R.D., Ostash, B.
Sci Rep. 2021, 11(1), 3507

217. "Pentapeptide repeat protein QnrB1 requires ATP hydrolysis to rejuvenate poisoned gyrase complexes."
Mazurek, L., Ghilarov, D., Michalczyk, E., Pakosz, Z., Metelev, M., Czyszczon, W., Wawro, K., Behroz, I., Dubiley, S., Süssmuth, R.D., Heddle, J.G.
Nucleic Acids Res. 2021, 49(3), 1581-1596


2020



216. "Genetic analysis of Streptomyces albus J1074 mia mutants suggests complex relationships between post-transcriptional tRNAXXA modifications and physiological traits."
Koshla, O., Kravets, V., Dacyuk, Y., Ostash, I., Süssmuth, R.D., Ostash*, B.
Folia Microbiol. 2020, 65(6), 1009-1015

215. "An amphipathic alpha-helix guides maturation of the ribosomally-synthesized lipolanthines."
Wiebach, V., Mainz, A., Schnegotzki, R., Siegert, M.J., Hügelland, M., Pliszka, N., Süssmuth*, R.D.
Angew. Chem. Int. Ed. 2020, 59(38), 16777-16785
"Eine amphipathische alpha-Helix lenkt die Modifizierung ribosomal-synthetisierter Lipolanthine."
Wiebach, V., Mainz, A., Schnegotzki, R., Siegert, M.J., Hügelland, M., Pliszka, N., Süssmuth*, R.D.
Angew. Chem. 2020, 132, 16920-16929

214. "Concentration dependency of the unbound partition coefficient Kp_uu and its application to correct for exposure related discrepancies between biochemical and cellular potency of KAT6A inhibitors."
Trünkle, C., Lechner, C., Korr, D., Bouché, L., Barak, N., Fernández-Montalván, A., Süssmuth, R.D., Reichel*, A.
Drug. Metab. Dispos. 2020, 48(7), 553-562

213. "Extended Snake Venomics by Top-Down in-Source Decay: Investigating the Newly Discovered Anatolian Meadow Viper Subspecies, Vipera anatolica senliki."
Hempel, B.F., Damm, M., Mrinalini, Göcmen, B., Karis, M., Nalbantsoy, A., Kini, R.M., Süssmuth*, R.D.
J. Proteome Res. 2020, 19(4), 1731-1749

212. "Self-Assembled Monolayer Epitope Bridges for Molecular Imprinting and Cancer Biomarker Sensing."
Drzazgowska, J., Schmid, B.A., Süssmuth, R.D., Altintas, Z.
Anal. Chem. 2020, 92(7), 4798-4806

211. "Short self-assembling cationic antimicrobial peptide mimetics based on a 3,5-diaminobenzoic acid scaffold."
Thota, C.K., Berger, A.A., Harms, B., Seidel, M., Böttcher, C., von Berlepsch, H., Xie, C., Süssmuth, R.D., Roth, C., Koksch, B.
Pep. Sci. 2020, 112(1), e24130

210. "A Convergent Total Synthesis of the Death Cap Toxin alpha-Amanitin
."
Siegert, M.J., Knittel, C.H., Süssmuth*, R.D.
Angew. Chem. Int. Ed. 2020, 59(14), 5500-5504
"Eine konvergente Totalsynthese des Pilztoxins alpha-Amanitin."
Siegert, M.J., Knittel, C.H., Süssmuth*, R.D.
Angew. Chem. 2020, 132(14), 5542-5546

209. "Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis."
Prochnow, H., Rox, K., Suryanarayana Birudukota, N.V., Weichert, L., Hotop, S.-K., Klahn, P., Mohr, K., Franz, S., Banda, D., Blockus, S., Schreiber, J., Haid, S.,
Oeyen, M., Martinez, J.P., Süssmuth, R.D., Wink, J., Meyerhans, A., Goffinet, C., Messerle, M., Schulz, T.F., Kröger, A., Schols, D., Pietschmann, T., Brönstrup, M.
J. Virol. 2020, 94(2), pii: e01471-19


2019


208. "Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals."
Casewell, N., Petras, D., Card, D.C., Suranse, V., Mychajliw, A.M., Richards, D., Koludarov, I., Albulescu, L.O., Slagboom, J., Hempel, B.F., Ngum, N.M., Kennerley, R.J.,
Whiteley, G., Harrison, R.A., Bolton, F.M.S., Debono, J., Vonk, F.J., Alföldi, J., Johnson, J., Karlsson, E.K., Lindblad-Toh, K., Mellor, I.R., Süssmuth, R.D., Fry, B.G.,
Kuruppu, S., Hodgson, W.C., Kool, J., Castoe, T.A., Barnes, I., Sunagar, K., Undheim, E.A.B., Turvey, S.T.
Proc. Natl. Acad. Sci. U.S.A. 2019, 116(51), 25745-25755

207. "Extensive Structure-Activity Relationship Study of Albicidin's C-Terminal Dipeptidic p-Aminobenzoic Acid Moiety."
Behroz, I., Durkin, P., Grätz, S., Seidel, M., Rostock, L., Spinczyk, M., Weston, J.B., Süssmuth*, R.D.
Chem. Eur. J. 2019, 25, 16538-16543

206. "Probing Exchange Units for Combining Iterative and Linear Fungal Nonribosomal Peptide Synthetases."
Steiniger, C., Hoffmann, S., Süssmuth*, R.D.
Cell Chem. Biol. 2019, 26(11), 1526-1534

205. "Lichenicidin rational site-directed mutagenesis library: a tool to generate bioengineered lantibiotics."
Barbosa, J., Caetano, T., Moesker, E., Süssmuth, R.D., Mendo*, S.
Biotechnol. Bioeng. 2019,116(11), 3053-3062

204. "Noursamycins, Chlorinated Cyclohexapeptides Identified from Molecular Networking of Streptomyces noursei NTR-SR4."
Mudalungu, C.M., von Törne, W.J., Voigt, K., Rückert, C., Schmitz, S., Sekurova, O.N., Zotchev, S.B., Süssmuth*, R.D.
J. Nat. Prod. 2019, 82(6), 1478-1486

203. "Unlocking the spatial control of secondary metabolism uncovers hidden natural product diversity in Nostoc punctiforme."
Dehm, D., Krumbholz, J., Baunach, M., Wiebach, V., Hinrichs, K., Guljamow, A., Tabuchi, T., Jenke-Kodama, H., Süssmuth, R.D., Dittmann*, E.
ACS Chem. Biol. 2019, 14(6), 1271-1279

202. "Total synthesis of the death cap toxin Phalloidin - atropoisomer-selectivity explained by molecular-dynamics simulations."
Yao, G., Joswig, J.O., Keller, B.G., Süssmuth*, R.D.
Chemistry. 2019, 25(34), 8030-8034

201. "Gene miaA for post-transcriptional modification of tRNAXXA is important for morphological and metabolic differentiation in Streptomyces."
Koshla, O., Yushchuk, O., Ostash, I., Dacyuk, Y., Myronovskyi, M., Jäger, G., Süssmuth, R.D., Luzhetskyy, A., Byström, A., Kirsebom, L.A., Ostash*, B.
Mol. Microbiol. 2019, 112(1), 249-265

200. "Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines."
Knebel, C., Buhrke, T., Süssmuth, R.D., Lampen, A., Marx-Stoelting*, P., Braeuning, A.
Arch. Toxicol. 2019, 93(5), 1311-1322

199. "Secondary Metabolome and Transcriptome of Streptomyces albus J1074 in Liquid Medium SG2."
Koshla, O.T., Rokytskyy, I.V., Ostash, I.S., Busche, T., Kalinowski, J., Mösker, E., Süssmuth, R.D., Fedorenko, V.O., Ostash*, B.O.
Cytol. Genet. 2019, 53(1), 1-7

198. "Desymmetrization of Cyclodepsipeptides by Assembly Mode Switching of Iterative Non-ribosomal Peptide Synthetases."
Steiniger, C., Hoffmann, S., Süssmuth*, R.D.
ACS Synth. Biol. 2019, 8(4), 661-667

197. "Investigating the cytotoxic effects of the venom proteome of two species of the Viperidae family (Cerastes cerastes and Cryptelytrops purpureomaculatus) from various habitats."
Ozverel, C.S., Damm, M., Hempel*, B.-F., Göcmen, B., Sroka, R., Süssmuth, R.D., Nalbantsoy*, A.
Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2019, 220, 20-30

196. "How many O-donors in enterobactin does it take to bind a metal?"
Baramov, T., Schmid, B., Ryu, H., Jeong, J., von Eckardstein, L., Baik*, M.H., Süssmuth*, R.D.
Chemistry. 2019, 25(28), 6955-6962

195. "Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey."
Petras*, D., Hempel, B.-F., Göcmen, B., Karis, M., Whiteley, G., Wagstaff, S.C., Heiss, P., Casewell, N.R., Nalbantsoy, A., Süssmuth, R.D.
J. Proteomics. 2019, 119, 31-50

194. "Integrated Approaches Toward High-Affinity Artificial Protein Binders Obtained via Computationally Simulated Epitopes for Protein Recognition."
Altintas*, Z., Takiden, A., Utesch, T., Mroginski, M.A., Schmid, B., Scheller, F.W., Süssmuth, R.D.
Adv. Funct. Mater. 2019, 29, 1807332


193. "The biosynthetic implications of the late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis."
Schoppet, M., Peschke, M., Kirchberg, A., Wiebach, V., Süssmuth, R.D., Stegmann, E., Cryle*, M.J.
Chem. Sci. 2019, 10, 118-133


192. "Recognition of protein biomarkers using epitope-mediated m."
Tchinda, R., Tutsch, A., Schmid, B., Süssmuth, R.D., Altintas*, Z.
Biosens. Bioelectron. 2019, 123, 260-268


191. "Comparison of actinomycin peptide synthetase formation in Streptomyces chrysomallus and Streptomyces antibioticus."
Crnovcic, I., Lang, M., Ortel, I., Süssmuth, R.D., Keller*, U.
J. Basic Microbiol. 2019, 59(2), 148-157



2018


190. "Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand."
Knebel, C., Kebben, J., Eberini, I., Palazzolo, L., Hammer, H.S., Süssmuth, R.D., Heise, T., Hessel-Pras, S., Lampen, A., Braeuning, A., Marx-Stoelting*, P.
Arch. Toxicol. 2018,
92(12), 3471-3486

189. "Molecular insights into antibiotic resistance - how a binding protein traps albicidin."
Rostock, L., Driller, R., Grätz, S., Kerwat, D., von Eckardstein, L., Petras, D., Kunert, M., Alings, C., Schmitt, F.-J., Friedrich, T., Wahl, M.C., Loll, B., Mainz, A., Süssmuth*, R.D.
Nat. Commun. 2018, 9(1), 3095