Albicidin
Feglymycin
Class II Lanthipeptides
Class III Lanthipeptides
CDPs
Paenilamicin
Abyssomicin
Salmochelin
Skyllamycin
MembraTech



Paenilamicin

 


Coworkers: Sebastian Gensel, Tam Dang

Keywords: Paenilamicin, American Foulbrood, Synthesis, PKS/NRPS

Cooperation: PD Dr. Elke Genersch, Länderinstitut für Bienenkunde

 

 



The paenilamicins are highly water-soluble naturally occurring peptides which are isolated from the Gram-positive bacterium Paenibacillus larvae. This bacterium is the causative agent of the disastrous  American Foulbrood disease affecting honey bee larvae. Derived from a polyketide synthase/nonribosomal-peptide synthetase hybrid assembly the paenilamicins harbor a unique structure (Figure 1). Besides their PKS-derived polyol-units trihydroxypentanoic acid (Hpa) and galantinic acid (Gla), the four isolated derivatives are strongly decorated with several amino-moieties, e.g. 4,3-spermidine at the C-terminus. We elucidated the structure of the paenilamicins by means of NMR spectroscopy and GC-MS analysis, and established a complete picture of the biosynthetic assembly (Figure 2). Antibacterial and antifungal testing showed activity against various species, making paenilamicins interesting targets for further investigation into their so far elusive mode of action.