Class II Lanthipeptides
Class III Lanthipeptides

Salmochelin and Enterobactin: Synthesis of Iron-Siderophores


Coworkers: Bianca Schmid

Keywords: Enterobactin, Salmocholin, Siderophores

Cooperation: Prof. Karl Hantke, University of Tübingen, Prof. Mu-Hyun Baik, KAIST, Daejeon, South Korea



Iron is an essential cofactor for the most bacteria species. Due to low Fe3+ availability in the environment bacteria synthesize special iron-binding molecules called siderophores with a high iron affinity. Enterobactin, produced by several enterobacteria strains, is one of the best studied siderophores and proved to be the strongest iron chelator known so far. Recently Salmochelin, a C-glycolysed Entero­bactin analogue was isolated and structurally characterized. Salmochelin and Entero­bactin have now been found to also bind silicon ions with high affinity, giving the first examples of silicon complexes of natural products stable under physiological conditions.

Figure 1. Structures of a) Enterobactin and b) Salmochelin S4

Our field of research is the novel synthesis of Enterobactin and Salmochelin analogues to further investigate the influence of the substituents on the binding properties and the 3D-structure.

Figure 2.