Albicidin
Feglymycin
Class II Lanthipeptides
Class III Lanthipeptides
CDPs
Paenilamicin
Abyssomicin
Salmochelin
Skyllamycin
MembraTech



Skyllamycin: Insights into biosynthesis and total synthesis

 


Coworkers: Melanie Gonsior

Keywords: nonribosomal peptide synthesis, cyclodepsipeptides, elucidation, total synthesis

Cooperation: Prof. Max Cryle, EMBL Australia, Prof. Holger Dobbek, HU Berlin

 

 





Skyllamycin A and B belong to the important group of cyclodepsipeptide secondary metabolites that are produced by bacteria and fungi and are pharmaceutically used as  antibacterials,  immunosuppressives,  cytostatics  and  antihelmintics.  First  isolated from Streptomyces sp. KY 11784 but recently reisolated from Streptomyces sp. Acta 2897,  skyllamycin A  was  shown  to  selectively  inhibit  the  binding  of  one  type  of platelet-derived growth factor (PDGF BB) to its extracellular domain of the PDGF β-receptor with an interesting IC 50 of 11 µM.PDGF signalling pathways are involved in important cell processes like proliferation and migration and show hyperactivity in tumour cells.